USER INTERFACES CAD SOFTWARE FOR PRE- AND POST- PROCESSING OF MODELS ACCOMPANYING PAK FE CODE
This paper introduces the CAD user interface software developed to support example-driven simulations using the PAK finite element code. Built upon years of research and development by the authors, CAD represents a custom-built platform for three-dimensional model setup and result visualization, tightly integrated with the PAK solver. It facilitate...
By Miljan Milošević, Vladimir Simić, Bogdan Milićević, Velibor Isailović, Vladimir Ranković, Miloš Ivanović, Žarko Milošević, Dalibor Nikolić, Danko Milašinović, Arso Vukićević, Lazar Otašević, Mileta Stojanović, Nenad Filipović, Miloš Kojić, Boban Stojanović
COMPUTATIONAL MODELING AND PARAMETRIC STUDY OF CIRCULATING TUMOR CELL (CTC) MOTION AND ATTACHMENT IN CAPILLARIES WITH PLATELET INTERACTION AND ACTIVATION
Metastasis involves the dissemination of circulating tumor cells (CTCs) from the primary tumor, their survival in the bloodstream, and eventual colonization of distant organs. Adhesive interactions with platelets, leukocytes, and endothelial cells are critical to CTC survival and extravasation. Platelet adhesion enhances CTC viability and promotes ...
By Vladimir Simić, Miljan Milošević, Aleksandar Nikolić, Shao Ning, Xuewu Liu, Fransisca Leonard, Miloš Kojić
COMPUTATIONAL MODELING OF DRUG TRANSPORT AND PERFUSION WITHIN COMPLEX BIOLOGICAL SYSTEMS AND GROWING TUMORS
Mass transport is a fundamental process in living organisms, responsible for the delivery of oxygen, nutrients, and drugs from blood vessels to tissues, as well as the removal of waste products back to the vascular and lymphatic systems. This exchange occurs across various biological barriers, including blood vessel walls and cellular membranes, an...
By Vladimir Simić, Miljan Milošević, Bodan Milićević, E.J. Koay, Xuewu Liu, Antonio Martino, Rossana Terracciano, Carly Filgueira, Miloš Kojić
SMEARED CONCEPT FOR MODELING GRADIENT-DRIVEN PROBLEMS IN COMPOSITE MEDIA (KOJIC TRANSPORT MODEL, KTM) AS A BASIS FOR BROAD APPLICATIONS
The extremely complex biological and biochemical processes are mainly treated by laboratory and clinical investigations. In recent decades, the application of computational modeling has become more important in research and applications in the medical sciences. Despite enormous efforts and achievements in this modeling, there is still a need for ne...
By Miloš Kojić, Miljan Milošević, Vladimir Simić, Bogdan Milićević
HEART MODEL FOR ELECTROPHYSIOLOGY, MECHANICS AND BLOOD FLOW
Cardiovascular diseases are among the leading causes of mortality worldwide, necessitating advanced computational modeling to study their underlying mechanisms and explore potential treatments. In this paper, we present a multiphysics computational model that integrates cardiac mechanics, electrophysiology, and mass transport, implemented within th...
By Miljan Milošević, Bogdan Milićević, Vladimir Simić, Nenad Filipović, Miloš Kojić
MODELING MASS RELEASE FROM NANOFIBERS – THEORY AND APPLICATION
This study investigates the drug release performance of electrospun composite nanofiber mats, which hold significant promise as drug carriers for site-specific delivery in therapeutic applications such as cancer therapy. Predicting drug release rates from poly(D,L-lactic-co-glycolic acid) (PLGA) nanofibers produced via emulsion electrospinning is c...
By Miljan Milošević, Vladimir Simić, Bodan Milićević, Dušica Stojanović, Mirjana Grković, Miloš Bjelović, Petar Uskoković, Miloš Kojić
BLOOD FLOW IN ARTERIAL BIFURCATION CALCULATED BY TURBULENT FINITE ELEMENT MODEL
In this paper, turbulent fluid flow is analyzed using a two-equation turbulent finite element model that can calculate values in the viscous sublayer. Implicit integration of the equations is used for determining the fluid velocity, fluid pressure, turbulence, kinetic energy, and dissipation of turbulent kinetic energy. These values are calculated ...
By Aleksandar Nikolić, Marko Topalović, Vladimir Simić, Milan Blagojević