This paper introduces the CAD user interface software developed to support example-driven simulations using the PAK finite element code. Built upon years of research and development by the authors, CAD represents a custom-built platform for three-dimensional model setup and result visualization, tightly integrated with the PAK solver. It facilitate...

By Miljan Milošević, Vladimir Simić, Bogdan Milićević, Velibor Isailović, Vladimir Ranković, Miloš Ivanović, Žarko Milošević, Dalibor Nikolić, Danko Milašinović, Arso Vukićević, Lazar Otašević, Mileta Stojanović, Nenad Filipović, Miloš Kojić, Boban Stojanović

A water supply system with radial wells (RWs) extends usually over tens of kilometers horizontally and tens of meters deep within the soil. Water flows through the soil and then through several lateral screens to the vertical shaft. Lateral screens represent perforated pipes with lengths in meters and diameters measured in centimeters. A common app...

By Vladimir Ranković, Nenad Filipović, Boban Stojanović, Velibor Isailović, Miloš Kojić

Material transport by diffusion is present in nature, as well as in living organisms as a vital process. The basic and generally used is a phenomenologically established law, named Fick’s law, It states that the material flux is proportional to the concentration gradient and that the material flows from the higher to lower concentration. Howe...

By Miloš Kojić, Miljan Milošević, Alessandro Grattoni, Mauro Ferrari

Metastasis involves the dissemination of circulating tumor cells (CTCs) from the primary tumor, their survival in the bloodstream, and eventual colonization of distant organs. Adhesive interactions with platelets, leukocytes, and endothelial cells are critical to CTC survival and extravasation. Platelet adhesion enhances CTC viability and promotes ...

By Vladimir Simić, Miljan Milošević, Aleksandar Nikolić, Shao Ning, Xuewu Liu, Fransisca Leonard, Miloš Kojić

This review summarizes scientific findings from three European Commission FP7 projects. The first, ARTREAT (2008-2013), focused on a multi-level, patient-specific model of artery and atherogenesis for outcome prediction, treatment decision support, and virtual hands-on training. An original method for plaque formation and development was created an...

By Nenad Filipović, Miloš Radović, Tijana Đukić, Igor Saveljić, Bogdan Milićević, Exarchos Themis, Oberdan Parodi, Dimitris Fotiadis

Degradation of structural integrity and fatigue life estimation remain critical challenges in engineering, including biomedical applications. Fracture mechanics and crack propagation prediction are highly sensitive to material parameters, with the Stress Intensity Factor being the most significant physical parameter for the estimation of crack stre...

By Gordana Jovičić, Vladimir Milovanović, Aleksandra Vulović, Miroslav Živković, Nenad Đorđevič, Nenad Filipović

Dynamic analysis of engineering structures is essential in the design process, providing insights into their behavior under various loading conditions. This paper focuses on the comparative study of implicit and explicit dynamic analysis methods using the PAK software and FEMAP with the Nastran software. Both methods have distinct advantages and di...

By Vladimir Dunić, Miloš Pešić, Miroslav Živković, Radovan Slavković

This study presents the use of computational modeling to improve understanding of hypertrophic cardiomyopathy (HCM) and its progression to heart failure. A review of related work highlights advances and challenges in computational modeling and integration of clinical data for model development and validation. Using parametric model of the left hear...

By Smiljana Tomašević, Bogdan Milićević, Miljan Milošević, Nenad Filipović

Understanding the biomechanical response of a femoral bone under physiological loads is critical for assessing bone health and fracture risk, particularly in aging populations affected by osteopenia and osteoporosis. This study investigates the mechanical behavior of the femoral bone under standing loading conditions across three bone states: healt...

By Aleksandra Vulović, Gordana Jovičić, Nenad Filipović

This study investigates the drug release performance of electrospun composite nanofiber mats, which hold significant promise as drug carriers for site-specific delivery in therapeutic applications such as cancer therapy. Predicting drug release rates from poly(D,L-lactic-co-glycolic acid) (PLGA) nanofibers produced via emulsion electrospinning is c...

By Miljan Milošević, Vladimir Simić, Bodan Milićević, Dušica Stojanović, Mirjana Grković, Miloš Bjelović, Petar Uskoković, Miloš Kojić