COMPUTATIONAL MODELING AND PARAMETRIC STUDY OF CIRCULATING TUMOR CELL (CTC) MOTION AND ATTACHMENT IN CAPILLARIES WITH PLATELET INTERACTION AND ACTIVATION
Metastasis involves the dissemination of circulating tumor cells (CTCs) from the primary tumor, their survival in the bloodstream, and eventual colonization of distant organs. Adhesive interactions with platelets, leukocytes, and endothelial cells are critical to CTC survival and extravasation. Platelet adhesion enhances CTC viability and promotes ...
By Vladimir Simić, Miljan Milošević, Aleksandar Nikolić, Shao Ning, Xuewu Liu, Fransisca Leonard, Miloš Kojić
PENALTY CONTACT BETWEEN FEM AND SPH WITH FRICTION
The interaction between the Finite Element Method (FEM) and Smoothed Particle Hydrodynamics (SPH) is crucial in multiphysics simulations of granular–structure systems, impacts, and material behavior. This paper presents a penalty-based contact algorithm with Coulomb friction for FEM–SPH coupling. The method accounts for static and dynam...
By Marko Topalović, Miloš Ivanović, Snežana Vulović, Aleksandar Nikolić, Miroslav Živković
TURBULENT FLUID FLOW MODEL WITH APPLICATION IN BIOMEDICINE
Two-equation turbulent models are widely used in finite element analysis of fluid flow. The PAK program package was upgraded from the classical laminar flow to the turbulent k-omega model. The turbulence model was validated using the case of fluid flow in a backward-facing step channel. The analysis results show good agreement with experimental dat...
By Aleksandar Nikolić, Miroslav Živković, Nenad Filipović, Marko Topalović
FSI ANALYSIS WITH CONTINUOUS FLUID FLOW USING FEM AND SPH METHODS IN LS-DYNA
The purpose of this research was to investigate the prospect of continuous flow modelling in LS-DYNA using SPH-FEM coupling. The both methods (SPH and FEM) are based on the continuum mechanics, however, SPH implementation uses Lagrangian material framework, while FEM uses an Eulerian formulation for the fluid analysis, and Lagrangian formulation fo...
By Marko Topalović, Aleksandar Nikolić, Snežana Vulović, Vladimir P. Milovanović
BLOOD FLOW IN ARTERIAL BIFURCATION CALCULATED BY TURBULENT FINITE ELEMENT MODEL
In this paper, turbulent fluid flow is analyzed using a two-equation turbulent finite element model that can calculate values in the viscous sublayer. Implicit integration of the equations is used for determining the fluid velocity, fluid pressure, turbulence, kinetic energy, and dissipation of turbulent kinetic energy. These values are calculated ...
By Aleksandar Nikolić, Marko Topalović, Vladimir Simić, Milan Blagojević