Metastasis involves the dissemination of circulating tumor cells (CTCs) from the primary tumor, their survival in the bloodstream, and eventual colonization of distant organs. Adhesive interactions with platelets, leukocytes, and endothelial cells are critical to CTC survival and extravasation. Platelet adhesion enhances CTC viability and promotes ...

By Vladimir Simić, Miljan Milošević, Aleksandar Nikolić, Shao Ning, Xuewu Liu, Fransisca Leonard, Miloš Kojić

This review summarizes scientific findings from three European Commission FP7 projects. The first, ARTREAT (2008-2013), focused on a multi-level, patient-specific model of artery and atherogenesis for outcome prediction, treatment decision support, and virtual hands-on training. An original method for plaque formation and development was created an...

By Nenad Filipović, Miloš Radović, Tijana Đukić, Igor Saveljić, Bogdan Milićević, Exarchos Themis, Oberdan Parodi, Dimitris Fotiadis

This paper contains two parts – the first is related to the mechanics of lung microstructure, and the second is a formulation of a multiscale-multiphysics model of the lung. The second part considers the entire lung that relies on the mechanics of the microstructure and recently developed a multiscale composite finite element of the lung tiss...

By Miloš Kojić, Ivo Vlastelica, Boban Stojanović, Vladimir Ranković, Akira Tsuda

Finite element (FE) modeling the motion of deformable bodies within a fluid, as well as the interaction between the bodies, has been a continuous challenge over the years. There are in principle two approaches – loose and strong coupling between the FE models of the two domains, with their advantages and drawbacks. We here present our concept...

By Velibor Isailović, Miljan Milošević, Nikola Kojić, Miloš Kojić

Aortic dissection is a severe clinical condition that demands a thorough understanding of the interactions between the true and false lumens. In this study, numerical simulations were performed for two patients, generating two preoperative and two postoperative models. The analyses were carried out using the PAKSF solver, a specialized tool for flu...

By Igor Saveljić, Tijana Đukić, Smiljana Tomašević, Nenad Filipović

This study investigates the drug release performance of electrospun composite nanofiber mats, which hold significant promise as drug carriers for site-specific delivery in therapeutic applications such as cancer therapy. Predicting drug release rates from poly(D,L-lactic-co-glycolic acid) (PLGA) nanofibers produced via emulsion electrospinning is c...

By Miljan Milošević, Vladimir Simić, Bodan Milićević, Dušica Stojanović, Mirjana Grković, Miloš Bjelović, Petar Uskoković, Miloš Kojić

In silico clinical trials are set to transform medicine by enabling virtual testing and simulation, which streamline the development of medical devices and pharmaceuticals while reducing costs and duration. The SILICOFCM platform offers a innovative, multi-modular approach designed to optimize overall heart function and monitor the effectiveness of...

By Nenad Filipović, Igor Saveljić, Tijana Geroski, Smiljana Tomašević, Miljan Milošević, Bogdan Milićević, Momčilo Prodanović, Srboljub Mijailović, Miloš Kojić

This paper presents a method for improving the numerical analysis of contact problems using a penalty formulation. Since contact phenomena are inherently nonlinear, particularly in the case of large deformations, an incremental solution strategy is required. Conventional Newton-Raphson algorithms often face convergence problems when many nodes make...

By Snežana Vulović, Miroslav Živković, Nenad Grujović, Marko Topalović

The concrete damaged plasticity (CDP) model is one of the most popular constitutive models implemented into various Finite Element Method software. The application to the real structures is documented in the literature, but still there are some doubts about the response in combination with the various finite elements. Simple benchmark examples simu...

By Vladimir Dunić, Nenad Grujović, Aleksandar Bodić, Dragan Rakić, Miroslav Živković

The interaction between the Finite Element Method (FEM) and Smoothed Particle Hydrodynamics (SPH) is crucial in multiphysics simulations of granular–structure systems, impacts, and material behavior. This paper presents a penalty-based contact algorithm with Coulomb friction for FEM–SPH coupling. The method accounts for static and dynam...

By Marko Topalović, Miloš Ivanović, Snežana Vulović, Aleksandar Nikolić, Miroslav Živković