In silico clinical trials are set to transform medicine by enabling virtual testing and simulation, which streamline the development of medical devices and pharmaceuticals while reducing costs and duration. The SILICOFCM platform offers a innovative, multi-modular approach designed to optimize overall heart function and monitor the effectiveness of pharmacological treatments, aiming to decrease dependence on animal and human trials. It employs an integrated, multidisciplinary, and multiscale methodology to analyze patient-specific data, allowing the creation of personalized models that track disease progression. By combining data from various sources and scales with advanced computational techniques, SILICOFCM maps the flow of information from genetic mutations to organ dysfunction. The platform specifically targets hypertrophic (HCM) and dilated (DCM) cardiomyopathy through coupled macro- and micro-scale simulations utilizing finite element modeling of fluid-structure interaction (FSI) and molecular interactions within cardiac cells. This enables the simulation of left ventricular mechanics and the assessment of how different drugs influence electro-mechanical processes, including changes in calcium (Ca2+) handling and kinetic parameters. The overarching goal of the STRATIFYHF project is to develop and clinically validate an innovative AI-driven Decision Support System (DSS) to predict heart failure risk, support early diagnosis, and forecast disease progression—offering a paradigm shift in heart failure management across primary and secondary care. The DSS integrates patient-centered data from existing and emerging technologies, a digital patient library, and AI-based algorithms combined with computational modeling. Through workflows dedicated to improving heart performance and evaluating pharmacological effects, SILICOFCM and STRATIFYHF are paving new pathways to accelerate drug development and clinical testing.
Elliot SJ, Ni G, Mace BR, Lineton B. A wave finite element analysis of the passive cochlea. *The Journal of the Acoustical Society of America. 2013;133*(3:1535–45.
2.
Fahy F, Gardonio P. *Sound and structural vibration: Radiation, transmission and response*. 2006.
3.
Feynman R, Leighton R, Sands M. *The Feynman lectures on physics, Volume I: Mainly mechanics, radiation, and heat*. 2006.
4.
Filipovic N, Isailovic V, Milosevic Z, Nikolic D, Saveljic I, Radovic M, et al. Computational modeling of plaque development in the coronary arteries. *IFMBE Proceedings of the International Conference on Medical and Biological Engineering (CMBEBIH 2017)*. 2017;62:269–74.
5.
Filipovic N, Radovic M, Isailovic V, Milosevic Z, Nikolic D, Saveljic I, et al. Plaque formation and stent deployment with heating thermal effects in arteries. *Journal of the Serbian Society for Computational Mechanics. 2012;6*(1:11–28.
6.
Filipovic N, Mijailovic S, Tsuda A, Kojic M. An implicit algorithm within the arbitrary Lagrangian–Eulerian formulation for solving incompressible fluid flow with large boundary motions. *Computer Methods in Applied Mechanics and Engineering. 2006;195*(44–47:6347–61.
Greenwood DD. Critical bandwidth and the frequency coordinates of the basilar membrane. *The Journal of the Acoustical Society of America. 1961;33*(10:1344–56.
9.
Grossmann C, Roos H, Stynes M. *Numerical treatment of partial differential equations*. 2007.
10.
Isailovic V, Nikolic M, Bibas T, Sakellarios A, Tachos N, Milosevic M, et al. Numerical simulation of human hearing system. *EAI Endorsed Transactions on Pervasive Health and Technology. 2018;4*(13:3.
11.
Isailovic V, Nikolic M, Nikolic D, Saveljic I, Filipovic N. Using finite element method for modeling of mechanical response of cochlea and organ of Corti. In: *ICIST 2016 Proceedings*. 2016. p. 102–5.
12.
Isailovic V, Nikolic M, Milosevic Z, Saveljic I, Nikolic D, Radovic M, et al. Finite element coiled cochlea model. In: *AIP Conference Proceedings. 2015. p. 070015.
13.
Isailovic V, Nikolic M, Milosevic Z, Saveljic I, Nikolic D, Radovic M, et al. Finite element model of cochlea – Air conduction and bone conduction. In: *ICIST 2015 Proceedings*. 2015. p. 19–21.
14.
Isailovic V, Obradovic M, Nikolic D, Saveljic I, Filipovic N. SIFEM project: Finite element modelling of the cochlea. In: *IEEE BIBE 2013 Proceedings*. 2014. p. 1–4.
15.
Kevorkian J. *Partial differential equations: Analytical solution techniques*. 1999.
16.
Kojic M, Bathe KJ. *Inelastic analysis of solids and structures*. 2005.
17.
Kojic M, Slavkovic R, Zivkovic M, Grujovic N. *Metod konacnih elemenata I – linearna analiza*. Mašinski fakultet u Kragujevcu. 1998;
18.
Manoussaki D, Chadwick R. Effects of geometry on fluid loading in a coiled cochlea. *SIAM Journal on Applied Mathematics. 2006;61*(2:369–86.
Myklestadt NO. The concept of complex damping. *Journal of Applied Mechanics. 1952;19:284–6.
21.
Ni G. *Fluid coupling and waves in the cochlea*. 2012.
22.
Nikolic M. Lab-on-a-chip for lung tissue from in silico perspective. In: *Cardiovascular and Respiratory Bioengineering*. 2022.
23.
Nikolic M, Sustersic T, Filipovic N. Numerical simulation of sedimentation process using Mason–Weaver equation. *IEEE BIBE. 2021;
24.
Nikolic M, Filipovic N. Lung on a chip and epithelial lung cells modelling. In: *Computational Modeling in Bioengineering and Bioinformatics*. 2020. p. 105–35.
25.
Nikolic M, Sustersic T, Muller CB, Zhang YS, Vrana NE, Filipovic N. Monocyte behaviour under perfusion conditions for development of granuloma on-a-chip. In: *TERMIS EU 2019 Conference Book*. 2019.
26.
Nikolic M, Sustersic T, Saveljic I, Vrana NE, Filipovic N. Modelling of monocytes behaviour inside the bioreactor. In: *Belgrade BioInformatics Conference. 2018. p. 123.
27.
Nikolic M. *Elektro-mehanički model kohlee i analiza odziva modela*. 2017.
28.
Nikolic M, Teal P, Isailovic V, Filipovic N. Finite element cochlea box model – Mechanical and electrical analysis of the cochlea. In: *AIP Conference Proceedings. 2015. p. 070012.
29.
Obradović M, Avilla A, Thiagalingam A, Filipović N. Finite element modeling of the endocardial radiofrequency ablation. *Journal of the Serbian Society for Computational Mechanics. 2010;4*(2:43–53.
30.
Saveljic I, Nikolic D, Milosevic Z, Isailovic V, Nikolic M, Parodi O, et al. 3D modeling of plaque progression in the human coronary artery. In: *ICEM 2018 Proceedings*. 2018. p. 1–6.
31.
Smith GD. *Numerical solution of partial differential equations: Finite difference method*. 1985.
32.
Stolze CH. A history of the divergence theorem. *Historia Mathematica. 1978;5*(4:437–42.
33.
Vulovic R, Nikolic M, Filipovic N. Smart platform for the analysis of cupula deformation caused by otoconia presence within SCCs. *Computer Methods in Biomechanics and Biomedical Engineering. 2019;22*(2:130–8.
34.
Wang X, Wang L, Zhou J, Hu Y. Finite element modelling of human auditory periphery including a feed-forward amplification of the cochlea. *Computer Methods in Biomechanics and Biomedical Engineering. 2012;17*(10:1096–107.
35.
Yoon Y, Puria S, Steele CR. Frequency and spatial response of basilar membrane vibration in a three-dimensional gerbil cochlear model. *Journal of Mechanics of Materials and Structures. 2007;2*(8.
36.
Zienkiewicz OC. *The finite element method*. 1983.
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