Today, it takes ten to twelve years on average to complete a clinical trial before a new drug is approved and brought to marktet. Moreover, the evaluation of the efficacy and safety of drugs or devices has been performed in the linear and sequential manner with limited change over the past decade. The InSilc project is an EU funded project (www.ins...

By Milica Kaplarević, Marija Gačić, Georgia Karanasiou, Dimitris Fotiadis, Nenad Filipović

In this paper, a numerical investigation using the finite element method on the cooling capacity of an electronic heat sink has been presented. This heat sink is intended for cooling applications of micro-computer CPUs. It deals with a parallelepipedal block with rectangular fins, filled with a nanofluid and crossed by four cylindrical pipes in whi...

By Yamina Anouar, Abderrahim Mokhefi

Considering the important role of small parameter perturbation term in mechanical systems, the perturbed dynamic differential equations of Lagrange systems are established. The basic idea and method of solving ordinary differential equations by normal renormalization group method are transplanted into a kind of Lagrange mechanical systems, the reno...

By Zheng Mingliang

The difficulties associated with thrust-optimized contour nozzles have led to significant advances in our knowledge of the physical phenomena associated with flow separation. In this study, a fully implicit scheme is implemented using a combined weight function for splitting the flux to analyze the shock patterns in the optimized contour (TOC) that...

By Bensayah Khaled, Kamri Khadidja

This is a feasibility study for the application of a novel concept of single-needle device for localized chemotherapy. Systemic chemotherapy has numerous and severe side effects. To conduct localized (electro)chemotherapy, we designed a novel device that does not currently exist on the market. Electrochemotherapy is based on the cell membranes temp...

By Aleksandar Cvetković, Danijela Cvetković, Danko Milašinović, Nemanja Jovičić, Nikola Miailović, Dalibor Nikolić, Slobodanka Mitrović, Nenad Filipović

Efficient memory handling is one of the key issues that engineers and programmers face in developing software for numerical analysis such as the Finite Element Method. This method operates on huge matrices that have a large number of zero coefficients which waste memory, so it is necessary to save it and to work only with non-zero coefficients usin...

By Dragoljub Stevanović, Marko Topalović, Miroslav Živković

The perpetual points have been defined recently as characteristic points in a dynamical system. In many unexcited linear and nonlinear mechanical systems, the perpetual points are associated with rigid body motions and form the perpetual manifolds. The mechanical systems that admit rigid body motions as solutions are called perpetual. In the extern...

By Fotios Georgiades

Thermal diffusion and variable thermal conductivity effects on unsteady magnetohydrodynamic (MHD), heat and mass transfer flow past an infinite vertical porous plate have been investigated and analyzed numerically. The resultant flow governing equations are resolved numerically by the finite-difference scheme of the Crank-Nicolson type implicit met...

By M. Santha Raju, G.S.S. Raju

Due to extensive research efforts within the past thirty years, the mechanisms by which bubbles transfer energy during pool boiling are relatively well understood and have various applications in reactors, rockets, distillation, air separation, refrigeration and power cycles. In this paper, CFD analysis of heat transfer characteristics in nucleate ...

By Andrijana Stojanović, Srđan Belošević, Nenad Crnomarković, Ivan Tomanović, Aleksandar Milićević

Heart wall tissue plays a crucial role in living organisms by generating the mechanical force for blood flow. This tissue has a complex internal structure comprised mostly of muscle cells, in which biochemical energy is transformed into mechanical active stress under rhythmical electrical excitation. The overall heart functioning depends, among oth...

By Miloš Kojić, Miljan Milošević, Bogdan Milićević, Vlada Geroski, Vlada Simić, D. Trifunović, G. Stanković, Nenad Filipović