Home
About
About the Journal Open Access Statement Aims and Scope JSSCM Publication Summary Instructions for Authors Goals of Journal of the Serbian Society for Computational Mechanics Ethics and malpractice statements
Current Archive Editorial Board News Contact
×
Home

About the Journal Open Access Statement Aims and Scope JSSCM Publication Summary Instructions for Authors Goals of Journal of the Serbian Society for Computational Mechanics Ethics and malpractice statements
Current Archive Editorial Board News Contact
Research paper
Published: 01.12.2019.
<< Prev | Next >>
PDF
https://doi.org/10.24874/jsscm.2020.14.01.01

MULTISCALE COMPOSITE 3D FINITE ELEMENT FOR LUNG MECHANICS

By
Milos Kojic
Milos Kojic
View authors publications

Search this author on:

PubMed | Google Scholar

Abstract

The lungs are the pair of organs where very complex internal microstructure provides gas exchange as the vital process of living organisms. This exchange in humans occurs within only 300g of tissue but on the surface of millions of alveoli with the total surface area of around 130m2. The extremely complex microstructure consists of micron-size interconnected channels and alveoli, which significantly change the size during breathing and remain open. These conditions are maintained due to existence of two mechanical systems – one external and the other internal, which act in the opposite sense, so that the lung behaves as a tensegrity system. Many computational models, with various degrees of simplifications and sophistication have been introduced. However, this task remains a challenge. We here introduce a 3D multi-scale composite FE for mechanics of lung tissue (MSCL). The model can be further used in generating computational models for mechanics for the entire lung and coupling to airflow.

Keywords:

mechanics of lung microstructure,
multi-scale 3D composite finite element,
lung tissue material models,
surfactant

References

1.
Fukaya H, Martin C, Young A, Katsura S. Mechanical Properties of Alveolar Walls. J Appl Physiol. 1968;(6):689–95.
2.
Fukuoka Y, Kawataa Y, Nikia N, Umetanib K, Nakanoc Y, Ohmatsud H, et al. Microstructure analysis of the secondary pulmonary lobules by 3D synchrotron radiation CT. Medical Imaging: Computer-Aided Diagnosis. 2014;1–7.
3.
Fuller B. Tensegrity Portfolio and Art News Annual. 1961;112–27.
4.
Greaves I, Hildebrandt J, Hoppin. Micromechanics of the Lung, Handbook of Physiology -Chapter 14 The Respiratory System. 2010;
5.
Henry FS, Butler JP, Tsuda A. Kinematically irreversible flow and aerosol transport in the pulmonary acinus: A departure from classical dispersive transport. J Appl Physiol. 2002;92:835–45.
6.
Hildebrandt J, Fukaya H, Martin C. Stress-Strain Relations of Tissue Sheets Undergoing Uniform Two-Dimensional Stretch. J Appl Physiol. 1969;(5):758–62.
7.
Ingber D, Tensegrity I. Cell structure and hierarchical systems biology. J Cell Sci. 2003;1157–73.
8.
Kojic M, Tsuda A. Gravitational deposition of aerosols from oscillatory laminar pipe flows. J Aerosol Science. 2004;245–61.
9.
Kojic M, Bathe K. Inelastic Analysis of Solids and Structures. . Springer. 2005;
10.
Kojic M, Vlastelica I, Stojanovic B, Rankovic V, Tsuda A. Stress integration procedures for a biaxial isotropic material model of biological membranes and for hysteretic models of muscle fibers and surfactant. Int J Num Meth Engng. 2006;893–909.
11.
Kojic M, Filipovic N, Stojanovic B, Kojic N. Computer Modeling in Bioengineering. . J Wiley and Sons. 2008;
12.
Kojic M, Slavkovic R, Zivkovic M, Grujovic N, Filipovic N. PAK -Finite Element Program for Srtuctural Analysis, Field Problems and Biomechanics. 2010;
13.
Kojic M, Butler J, Vlastelica I, Stojanovic B, Rankovic V, Tsuda A. Geometric hysteresis of alveolated ductal architecture. ASME J Biomechanics. 2011;1–11.
14.
Kojic M, Milosevic M, Simic V, Ferrari M. A 1D pipe finite element with rigid and deformable walls. J Serb Soc Comp Mech. 2014;(2):38–53.
15.
Liu C, Niranjan S, Clark J, San K, Zwischenberger J, Bidani A. Airway mechanics, gas exchange, and blood flow in a nonlinear model of the normal human lung. J Appl Physiol. 1998;(4):1447–69.
16.
Miki H, Butler J, Roger R, Lehr J. Geometric Hysteresis in Pulmonary Surfaceto-Volume Ratio during Tidal Breathing. J Appl Physiol. 1993;(4):1630–6.
17.
Sasaki H, Hoppin F, Jr. Hysteresis of Contracted Airway Smooth Muscle. J Appl Physiol: Respir Environ Exercise Physiol. 1979;(6):1251–62.
18.
Tsuda A, Henry F, Butler J. Chaotic Mixing of Alveolated Duct Flow in Rhythmically Expanding Pulmonary Acinus. J Appl Physiol. 1995;(3):1055–63.
19.
Tsuda A, Filipovic N, Haberthu¨r D, Dickie R, Matsui Y, Stampanoni M, et al. Finite element 3D reconstruction of the pulmonary acinus imaged by synchrotron Xray tomography. J Appl Physiol. 2008;964–76.
20.
Tsuda A, Laine-Pearson F, Hydon P. Why Chaotic Mixing of Particles is Inevitable in the Deep Lung. J Theor Biol. 2011;57–66.
21.
Weibel E. It Takes More than Cells to Make a Good Lung. Am J Respir Crit Care Med. 2013;(4):342–6.
22.
Weibel E. Morphometry of the human lung. . Academic, New York. 1963;
23.
Weibel E, Gil J. Structure-function relationships at the alveolar level. In Bioengineering Aspects of the Lung. 1977;1–81.
24.
Wilson T. Surface Tension-Surface Area Curves Calculated from Pressure-Volume Loops. J Appl Physiol: Respir Environ Exercise Physiol. 1982;(6):1512–20.
25.
Wilson T, Bachofen H. A Model for Mechanical Structure of Alveolar Duct. J Appl Physiol, Respir Environ Excercise Physiol. 1982;(4):1064–70.

Citation

Copyright

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Article metrics

Google scholar: See link
Issue image
Vol 14, Issue 1, 2020
MULTISCALE COMPOSITE 3D FINITE ELEMENT FOR LUNG MECHANICS THERMO-DIFFUSION AND HALL EFFECT ON RADIATING AND REACTING MHD CONVECTIVE HEAT ABSORBING FLUID PAST AN EXPONENTIALLY ACCELERATED VERTICAL POROUS PLATE WITH RAMPED TEMPERATURE A STOCHASTIC MODEL FOR CRACK INITIATION LIFE PREDICTION OF AN AUSTENITIC STAINLESS STEEL UNDER CONSTANT AMPLITUDE LOADING COMBINED EFFECT OF THERMAL RADIATION AND VISCOUS DISSIPATION ON UNSTEADY FREE CONVECTIVE MAGNETO-HYDRODYNAMIC FLOW THROUGH AN IRREGULAR CHANNEL ENHANCED DAMPING CHARACTERISTICS OF TIMOSHENKO BEAM ON ELASTIC AND METAMATERIAL FOUNDATIONS See full issue

Citations

Crossref Logo

4

Crossref Logo

Miljan Milosevic, Vladimir Simic, Aleksandar Nikolic, Ning Shao, Chihiro Kawamura Hashimoto, Biana Godin, Fransisca Leonard, Xuewu Liu, Milos Kojic

(2023)

Modeling critical interaction for metastasis between circulating tumor cells (CTCs) and platelets adhered to the capillary wall

Computer Methods and Programs in Biomedicine, 242()

10.1016/j.cmpb.2023.107810
Crossref Logo

Milos Kojic, Miljan Milosevic, Vladimir Simic, Bogdan Milicevic, Rossana Terracciano, Carly S. Filgueira

(2024)

On the generality of the finite element modeling physical fields in biological systems by the multiscale smeared concept (Kojic transport model)

Heliyon, 10(5)

10.1016/j.heliyon.2024.e26354
Crossref Logo

Palla Ranga Prasad, Ananya Singh, Keisha Gomes, Sutanu Dutta, Kenza E. Tharayil, Shwetha Prakash, Meghna Shenoy, Jagnoor Singh Sandhu, Naveena AN Kumar, Bharti Bisht, Bhisham Narayan Singh, Manash K. Paul

(2025)

Advances in Regenerative Medicine and Tissue Engineering

Biomedical Engineering, 31()

10.5772/intechopen.1010650
Crossref Logo

Miloš Kojić, Miljan Milošević, Arturas Ziemys

(2023)

Computational Models in Biomedical Engineering

, ()

10.1016/B978-0-323-88472-3.00004-9

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.