This paper introduces the CAD user interface software developed to support example-driven simulations using the PAK finite element code. Built upon years of research and development by the authors, CAD represents a custom-built platform for three-dimensional model setup and result visualization, tightly integrated with the PAK solver. It facilitate...

By Miljan Milošević, Vladimir Simić, Bogdan Milićević, Velibor Isailović, Vladimir Ranković, Miloš Ivanović, Žarko Milošević, Dalibor Nikolić, Danko Milašinović, Arso Vukićević, Lazar Otašević, Mileta Stojanović, Nenad Filipović, Miloš Kojić, Boban Stojanović

A water supply system with radial wells (RWs) extends usually over tens of kilometers horizontally and tens of meters deep within the soil. Water flows through the soil and then through several lateral screens to the vertical shaft. Lateral screens represent perforated pipes with lengths in meters and diameters measured in centimeters. A common app...

By Vladimir Ranković, Nenad Filipović, Boban Stojanović, Velibor Isailović, Miloš Kojić

Material transport by diffusion is present in nature, as well as in living organisms as a vital process. The basic and generally used is a phenomenologically established law, named Fick’s law, It states that the material flux is proportional to the concentration gradient and that the material flows from the higher to lower concentration. Howe...

By Miloš Kojić, Miljan Milošević, Alessandro Grattoni, Mauro Ferrari

Metastasis involves the dissemination of circulating tumor cells (CTCs) from the primary tumor, their survival in the bloodstream, and eventual colonization of distant organs. Adhesive interactions with platelets, leukocytes, and endothelial cells are critical to CTC survival and extravasation. Platelet adhesion enhances CTC viability and promotes ...

By Vladimir Simić, Miljan Milošević, Aleksandar Nikolić, Shao Ning, Xuewu Liu, Fransisca Leonard, Miloš Kojić

This paper contains two parts – the first is related to the mechanics of lung microstructure, and the second is a formulation of a multiscale-multiphysics model of the lung. The second part considers the entire lung that relies on the mechanics of the microstructure and recently developed a multiscale composite finite element of the lung tiss...

By Miloš Kojić, Ivo Vlastelica, Boban Stojanović, Vladimir Ranković, Akira Tsuda

Finite element (FE) modeling the motion of deformable bodies within a fluid, as well as the interaction between the bodies, has been a continuous challenge over the years. There are in principle two approaches – loose and strong coupling between the FE models of the two domains, with their advantages and drawbacks. We here present our concept...

By Velibor Isailović, Miljan Milošević, Nikola Kojić, Miloš Kojić

Mass transport is a fundamental process in living organisms, responsible for the delivery of oxygen, nutrients, and drugs from blood vessels to tissues, as well as the removal of waste products back to the vascular and lymphatic systems. This exchange occurs across various biological barriers, including blood vessel walls and cellular membranes, an...

By Vladimir Simić, Miljan Milošević, Bodan Milićević, E.J. Koay, Xuewu Liu, Antonio Martino, Rossana Terracciano, Carly Filgueira, Miloš Kojić

The extremely complex biological and biochemical processes are mainly treated by laboratory and clinical investigations. In recent decades, the application of computational modeling has become more important in research and applications in the medical sciences. Despite enormous efforts and achievements in this modeling, there is still a need for ne...

By Miloš Kojić, Miljan Milošević, Vladimir Simić, Bogdan Milićević

Huxley-type muscle models offer a physiologically grounded description of cardiac contraction but remain computationally prohibitive for large-scale, multi-scale simulations. This article reviews surrogate modeling strategies that alleviate these costs for ventricular biomechanics, with emphasis on data-driven (RNN/TCN/GRU) and physics-informed (PI...

By Bogdan Milićević, Miloš Ivanović, Boban Stojanović, Miljan Milošević, Miloš Kojić, Nenad Filipović

In this paper, we give a short overview of the basic concept of stress integration for inelastic material models. This methodology was introduced by the author, initially for thermo-elasticplastic and creep deformation of metals, termed as ‘effective-stress-function’ (ESF), and then generalized to the ‘governing parameter method&r...

By Miloš Kojić