Finite element (FE) modeling the motion of deformable bodies within a fluid, as well as the interaction between the bodies, has been a continuous challenge over the years. There are in principle two approaches – loose and strong coupling between the FE models of the two domains, with their advantages and drawbacks. We here present our concept...

By Velibor Isailović, Miljan Milošević, Nikola Kojić, Miloš Kojić

Mass transport is a fundamental process in living organisms, responsible for the delivery of oxygen, nutrients, and drugs from blood vessels to tissues, as well as the removal of waste products back to the vascular and lymphatic systems. This exchange occurs across various biological barriers, including blood vessel walls and cellular membranes, an...

By Vladimir Simić, Miljan Milošević, Bodan Milićević, E.J. Koay, Xuewu Liu, Antonio Martino, Rossana Terracciano, Carly Filgueira, Miloš Kojić

The extremely complex biological and biochemical processes are mainly treated by laboratory and clinical investigations. In recent decades, the application of computational modeling has become more important in research and applications in the medical sciences. Despite enormous efforts and achievements in this modeling, there is still a need for ne...

By Miloš Kojić, Miljan Milošević, Vladimir Simić, Bogdan Milićević

This paper presents the integration of muscle fatigue modeling into the finite element solver PAK, based on an extended version of Hill’s phenomenological model. While traditional muscle models focus primarily on force generation, this study incorporates fatigue dynamics to provide a more realistic representation of muscle performance over ti...

By Boban Stojanović, Miloš Kojić, Srboljub Mijailovich

This paper describes software developed based on numerical implementation of algorithms for coupled acoustic – structure interaction. This class of problems implies coupling of the fluid domain, with sound wave propagation, and the domain of solid, which vibrates under the pressure caused by sound waves from the fluid domain. The physical beh...

By Velibor Isailović, Nenad Filipović, Milica Nikolić, Miloš Kojić

Cardiovascular diseases are among the leading causes of mortality worldwide, necessitating advanced computational modeling to study their underlying mechanisms and explore potential treatments. In this paper, we present a multiphysics computational model that integrates cardiac mechanics, electrophysiology, and mass transport, implemented within th...

By Miljan Milošević, Bogdan Milićević, Vladimir Simić, Nenad Filipović, Miloš Kojić

Solvent removal by diffusion from a polymer solution occurs in various technological processes, such dry spinning of synthetic silk-like fibers. There, it is important to determine the diffusion coefficient which is dependent on the solvent concentration, assuming the validity of Fick’s law. In order to prove the internal diffusion within the...

By Nikola Kojić, Aleksandar Kojić, Miloš Kojić

This study investigates the drug release performance of electrospun composite nanofiber mats, which hold significant promise as drug carriers for site-specific delivery in therapeutic applications such as cancer therapy. Predicting drug release rates from poly(D,L-lactic-co-glycolic acid) (PLGA) nanofibers produced via emulsion electrospinning is c...

By Miljan Milošević, Vladimir Simić, Bodan Milićević, Dušica Stojanović, Mirjana Grković, Miloš Bjelović, Petar Uskoković, Miloš Kojić

In silico clinical trials are set to transform medicine by enabling virtual testing and simulation, which streamline the development of medical devices and pharmaceuticals while reducing costs and duration. The SILICOFCM platform offers a innovative, multi-modular approach designed to optimize overall heart function and monitor the effectiveness of...

By Nenad Filipović, Igor Saveljić, Tijana Geroski, Smiljana Tomašević, Miljan Milošević, Bogdan Milićević, Momčilo Prodanović, Srboljub Mijailović, Miloš Kojić

Huxley-type muscle models offer a physiologically grounded description of cardiac contraction but remain computationally prohibitive for large-scale, multi-scale simulations. This article reviews surrogate modeling strategies that alleviate these costs for ventricular biomechanics, with emphasis on data-driven (RNN/TCN/GRU) and physics-informed (PI...

By Bogdan Milićević, Miloš Ivanović, Boban Stojanović, Miljan Milošević, Miloš Kojić, Nenad Filipović