USER INTERFACES CAD SOFTWARE FOR PRE- AND POST- PROCESSING OF MODELS ACCOMPANYING PAK FE CODE
This paper introduces the CAD user interface software developed to support example-driven simulations using the PAK finite element code. Built upon years of research and development by the authors, CAD represents a custom-built platform for three-dimensional model setup and result visualization, tightly integrated with the PAK solver. It facilitate...
By Miljan Milošević, Vladimir Simić, Bogdan Milićević, Velibor Isailović, Vladimir Ranković, Miloš Ivanović, Žarko Milošević, Dalibor Nikolić, Danko Milašinović, Arso Vukićević, Lazar Otašević, Mileta Stojanović, Nenad Filipović, Miloš Kojić, Boban Stojanović
OUR MULTISCALE FINITE ELEMENT MODEL OF GROUNDWATER FLOW TO RADIAL WELL
A water supply system with radial wells (RWs) extends usually over tens of kilometers horizontally and tens of meters deep within the soil. Water flows through the soil and then through several lateral screens to the vertical shaft. Lateral screens represent perforated pipes with lengths in meters and diameters measured in centimeters. A common app...
By Vladimir Ranković, Nenad Filipović, Boban Stojanović, Velibor Isailović, Miloš Kojić
NUMERICAL HOMOGENIZATION AS A METHOD FOR MODELING CONSTRAINED DIFFUSION
Material transport by diffusion is present in nature, as well as in living organisms as a vital process. The basic and generally used is a phenomenologically established law, named Fick’s law, It states that the material flux is proportional to the concentration gradient and that the material flows from the higher to lower concentration. Howe...
By Miloš Kojić, Miljan Milošević, Alessandro Grattoni, Mauro Ferrari
COMPUTATIONAL MODELING AND PARAMETRIC STUDY OF CIRCULATING TUMOR CELL (CTC) MOTION AND ATTACHMENT IN CAPILLARIES WITH PLATELET INTERACTION AND ACTIVATION
Metastasis involves the dissemination of circulating tumor cells (CTCs) from the primary tumor, their survival in the bloodstream, and eventual colonization of distant organs. Adhesive interactions with platelets, leukocytes, and endothelial cells are critical to CTC survival and extravasation. Platelet adhesion enhances CTC viability and promotes ...
By Vladimir Simić, Miljan Milošević, Aleksandar Nikolić, Shao Ning, Xuewu Liu, Fransisca Leonard, Miloš Kojić
MECHANICS OF LUNG MICROSTRUCTURE AS A BASIS FOR LUNG MECHANICS, AND MULTISCALE-MULTIPHYSICS MODEL OF LUNG MECHANICS, AIRFLOW, BLOOD FLOW, AND DIFFUSION
This paper contains two parts – the first is related to the mechanics of lung microstructure, and the second is a formulation of a multiscale-multiphysics model of the lung. The second part considers the entire lung that relies on the mechanics of the microstructure and recently developed a multiscale composite finite element of the lung tiss...
By Miloš Kojić, Ivo Vlastelica, Boban Stojanović, Vladimir Ranković, Akira Tsuda
IMPLICIT STRESS INTEGRATION AND GOVERNING PARAMETER METHOD (GPM) AS A GENERAL CONCEPT FOR INELASTIC MATERIAL MODELS IN THE CODE PAK
In this paper, we give a short overview of the basic concept of stress integration for inelastic material models. This methodology was introduced by the author, initially for thermo-elasticplastic and creep deformation of metals, termed as ‘effective-stress-function’ (ESF), and then generalized to the ‘governing parameter method&r...
By Miloš Kojić
A MULTISCALE MULTIPHYSICS FINITE ELEMENT FOR LUNG
The previously formulated finite element for lung mechanics (MSCL) by the author is extended to include airflow and molecular transport by diffusion. The lung mechanics is analyzed in detail providing an insight into the deformation of the microstructural elements. Also, some refinements are introduced with respect to the previous model. Here, the ...
By Miloš Kojić
COMPUTATIONAL MODEL FOR HEART TISSUE WITH DIRECT USE OF EXPERIMENTAL CONSTITUTIVE RELATIONSHIPS
Heart wall tissue plays a crucial role in living organisms by generating the mechanical force for blood flow. This tissue has a complex internal structure comprised mostly of muscle cells, in which biochemical energy is transformed into mechanical active stress under rhythmical electrical excitation. The overall heart functioning depends, among oth...
By Miloš Kojić, Miljan Milošević, Bogdan Milićević, Vlada Geroski, Vlada Simić, D. Trifunović, G. Stanković, Nenad Filipović
MULTISCALE COMPOSITE 3D FINITE ELEMENT FOR LUNG MECHANICS
The lungs are the pair of organs where very complex internal microstructure provides gas exchange as the vital process of living organisms. This exchange in humans occurs within only 300g of tissue but on the surface of millions of alveoli with the total surface area of around 130m2. The extremely complex microstructure consists of micron-size inte...
By Milos Kojic
SMEARED CONCEPT AS A GENERAL METHODOLOGY IN FINITE ELEMENT MODELING OF PHYSICAL FIELDS AND MECHANICAL PROBLEMS IN COMPOSITE MEDIA
A generalization of the smeared concept for field problems, published in recent papers of the author and his collaborators, is presented in the paper. A composite smeared finite element CSFE is formulated. This generalization can serve as a theoretical background for further applications. A selected numerical example, related to convective-diffusiv...
By Milos Kojic