This paper contains two parts – the first is related to the mechanics of lung microstructure, and the second is a formulation of a multiscale-multiphysics model of the lung. The second part considers the entire lung that relies on the mechanics of the microstructure and recently developed a multiscale composite finite element of the lung tiss...

By Miloš Kojić, Ivo Vlastelica, Boban Stojanović, Vladimir Ranković, Akira Tsuda

Finite element (FE) modeling the motion of deformable bodies within a fluid, as well as the interaction between the bodies, has been a continuous challenge over the years. There are in principle two approaches – loose and strong coupling between the FE models of the two domains, with their advantages and drawbacks. We here present our concept...

By Velibor Isailović, Miljan Milošević, Nikola Kojić, Miloš Kojić

Aortic dissection is a severe clinical condition that demands a thorough understanding of the interactions between the true and false lumens. In this study, numerical simulations were performed for two patients, generating two preoperative and two postoperative models. The analyses were carried out using the PAKSF solver, a specialized tool for flu...

By Igor Saveljić, Tijana Đukić, Smiljana Tomašević, Nenad Filipović

Mass transport is a fundamental process in living organisms, responsible for the delivery of oxygen, nutrients, and drugs from blood vessels to tissues, as well as the removal of waste products back to the vascular and lymphatic systems. This exchange occurs across various biological barriers, including blood vessel walls and cellular membranes, an...

By Vladimir Simić, Miljan Milošević, Bodan Milićević, E.J. Koay, Xuewu Liu, Antonio Martino, Rossana Terracciano, Carly Filgueira, Miloš Kojić

The extremely complex biological and biochemical processes are mainly treated by laboratory and clinical investigations. In recent decades, the application of computational modeling has become more important in research and applications in the medical sciences. Despite enormous efforts and achievements in this modeling, there is still a need for ne...

By Miloš Kojić, Miljan Milošević, Vladimir Simić, Bogdan Milićević

In silico clinical trials are set to transform medicine by enabling virtual testing and simulation, which streamline the development of medical devices and pharmaceuticals while reducing costs and duration. The SILICOFCM platform offers a innovative, multi-modular approach designed to optimize overall heart function and monitor the effectiveness of...

By Nenad Filipović, Igor Saveljić, Tijana Geroski, Smiljana Tomašević, Miljan Milošević, Bogdan Milićević, Momčilo Prodanović, Srboljub Mijailović, Miloš Kojić

This paper presents a method for improving the numerical analysis of contact problems using a penalty formulation. Since contact phenomena are inherently nonlinear, particularly in the case of large deformations, an incremental solution strategy is required. Conventional Newton-Raphson algorithms often face convergence problems when many nodes make...

By Snežana Vulović, Miroslav Živković, Nenad Grujović, Marko Topalović

The concrete damaged plasticity (CDP) model is one of the most popular constitutive models implemented into various Finite Element Method software. The application to the real structures is documented in the literature, but still there are some doubts about the response in combination with the various finite elements. Simple benchmark examples simu...

By Vladimir Dunić, Nenad Grujović, Aleksandar Bodić, Dragan Rakić, Miroslav Živković

The interaction between the Finite Element Method (FEM) and Smoothed Particle Hydrodynamics (SPH) is crucial in multiphysics simulations of granular–structure systems, impacts, and material behavior. This paper presents a penalty-based contact algorithm with Coulomb friction for FEM–SPH coupling. The method accounts for static and dynam...

By Marko Topalović, Miloš Ivanović, Snežana Vulović, Aleksandar Nikolić, Miroslav Živković

Huxley-type muscle models offer a physiologically grounded description of cardiac contraction but remain computationally prohibitive for large-scale, multi-scale simulations. This article reviews surrogate modeling strategies that alleviate these costs for ventricular biomechanics, with emphasis on data-driven (RNN/TCN/GRU) and physics-informed (PI...

By Bogdan Milićević, Miloš Ivanović, Boban Stojanović, Miljan Milošević, Miloš Kojić, Nenad Filipović