This paper introduces the CAD user interface software developed to support example-driven simulations using the PAK finite element code. Built upon years of research and development by the authors, CAD represents a custom-built platform for three-dimensional model setup and result visualization, tightly integrated with the PAK solver. It facilitate...

By Miljan Milošević, Vladimir Simić, Bogdan Milićević, Velibor Isailović, Vladimir Ranković, Miloš Ivanović, Žarko Milošević, Dalibor Nikolić, Danko Milašinović, Arso Vukićević, Lazar Otašević, Mileta Stojanović, Nenad Filipović, Miloš Kojić, Boban Stojanović

This paper describes software developed based on numerical implementation of algorithms for coupled acoustic – structure interaction. This class of problems implies coupling of the fluid domain, with sound wave propagation, and the domain of solid, which vibrates under the pressure caused by sound waves from the fluid domain. The physical beh...

By Velibor Isailović, Nenad Filipović, Milica Nikolić, Miloš Kojić

Cardiovascular diseases are among the leading causes of mortality worldwide, necessitating advanced computational modeling to study their underlying mechanisms and explore potential treatments. In this paper, we present a multiphysics computational model that integrates cardiac mechanics, electrophysiology, and mass transport, implemented within th...

By Miljan Milošević, Bogdan Milićević, Vladimir Simić, Nenad Filipović, Miloš Kojić

Degradation of structural integrity and fatigue life estimation remain critical challenges in engineering, including biomedical applications. Fracture mechanics and crack propagation prediction are highly sensitive to material parameters, with the Stress Intensity Factor being the most significant physical parameter for the estimation of crack stre...

By Gordana Jovičić, Vladimir Milovanović, Aleksandra Vulović, Miroslav Živković, Nenad Đorđevič, Nenad Filipović

This study presents the use of computational modeling to improve understanding of hypertrophic cardiomyopathy (HCM) and its progression to heart failure. A review of related work highlights advances and challenges in computational modeling and integration of clinical data for model development and validation. Using parametric model of the left hear...

By Smiljana Tomašević, Bogdan Milićević, Miljan Milošević, Nenad Filipović

Understanding the biomechanical response of a femoral bone under physiological loads is critical for assessing bone health and fracture risk, particularly in aging populations affected by osteopenia and osteoporosis. This study investigates the mechanical behavior of the femoral bone under standing loading conditions across three bone states: healt...

By Aleksandra Vulović, Gordana Jovičić, Nenad Filipović

In silico clinical trials are set to transform medicine by enabling virtual testing and simulation, which streamline the development of medical devices and pharmaceuticals while reducing costs and duration. The SILICOFCM platform offers a innovative, multi-modular approach designed to optimize overall heart function and monitor the effectiveness of...

By Nenad Filipović, Igor Saveljić, Tijana Geroski, Smiljana Tomašević, Miljan Milošević, Bogdan Milićević, Momčilo Prodanović, Srboljub Mijailović, Miloš Kojić

Huxley-type muscle models offer a physiologically grounded description of cardiac contraction but remain computationally prohibitive for large-scale, multi-scale simulations. This article reviews surrogate modeling strategies that alleviate these costs for ventricular biomechanics, with emphasis on data-driven (RNN/TCN/GRU) and physics-informed (PI...

By Bogdan Milićević, Miloš Ivanović, Boban Stojanović, Miljan Milošević, Miloš Kojić, Nenad Filipović

Wave acoustic equation is implemented and solved using finite element method in PAK solver to simulate propagation of sound waves, that cause oscillations of ear’s components, such as cochlea (part of inner ear). To simulate mechanical behaviour of cochlea, behaviour of fluid in chambers and behaviour of basilar membrane which separates them ...

By Milica Nikolić, Velibor Isailović, Nenad Filipović

X-ray angiography is one of the diagnostic procedures applied in clinical practice to analyze the state of patient-specific coronary arteries. During this examination a parameter called fractional flow reserve (FFR) is invasively measured to quantitatively assess the existence of potential stenosis and its significance. The software proposed in thi...

By Tijana Đukić, Ognjen Pavić, Lazar Dašić, Tijana Geroski, Nenad Filipović