Understanding the biomechanical response of a femoral bone under physiological loads is critical for assessing bone health and fracture risk, particularly in aging populations affected by osteopenia and osteoporosis. This study investigates the mechanical behavior of the femoral bone under standing loading conditions across three bone states: healt...

By Aleksandra Vulović, Gordana Jovičić, Nenad Filipović

In silico clinical trials are set to transform medicine by enabling virtual testing and simulation, which streamline the development of medical devices and pharmaceuticals while reducing costs and duration. The SILICOFCM platform offers a innovative, multi-modular approach designed to optimize overall heart function and monitor the effectiveness of...

By Nenad Filipović, Igor Saveljić, Tijana Geroski, Smiljana Tomašević, Miljan Milošević, Bogdan Milićević, Momčilo Prodanović, Srboljub Mijailović, Miloš Kojić

Huxley-type muscle models offer a physiologically grounded description of cardiac contraction but remain computationally prohibitive for large-scale, multi-scale simulations. This article reviews surrogate modeling strategies that alleviate these costs for ventricular biomechanics, with emphasis on data-driven (RNN/TCN/GRU) and physics-informed (PI...

By Bogdan Milićević, Miloš Ivanović, Boban Stojanović, Miljan Milošević, Miloš Kojić, Nenad Filipović

Wave acoustic equation is implemented and solved using finite element method in PAK solver to simulate propagation of sound waves, that cause oscillations of ear’s components, such as cochlea (part of inner ear). To simulate mechanical behaviour of cochlea, behaviour of fluid in chambers and behaviour of basilar membrane which separates them ...

By Milica Nikolić, Velibor Isailović, Nenad Filipović

The COVID-19 pandemic has significantly impacted project implementation costs and caused delays across numerous industries. Various analysis found in the literature show that the predominant cause of project delays and higher costs have been people, material, and equipment movement restrictions, supply chain disruptions, and social distancing polic...

By Ilija Stojanović, Marko Selaković, Marija Gačić, Milica Kaplarević, Nenad Filipović

Over the last few decades, cardiovascular stents have emerged as crucial biomedical devices. Stents undergo cyclic physiological loading, which can lead to progressive accumulation of structural damage over time eventually resulting in a stent fracture. Considering the critical role of stents, it is necessary to assess their fatigue endurance and p...

By Gordana Jovičić, Aleksandra Vulović, Arso Vukićević, Nenad Đorđević, Nenad Filipović

Hypertrophic cardiomyopathy is one of the most prominent cardiovascular diseases, with almost 1 in 500 people suffering from it. It is of great importance for this disease to be detected in a timely manner, so that patients can be provided with an adequate therapy. This is also important for monitoring the future development of the disease so that ...

By Ognjen Pavić, Lazar Dašić, Tijana Geroski, Mina Vasković Jovanović, Nenad Filipović

This is a feasibility study for the application of a novel concept of single-needle device for localized chemotherapy. Systemic chemotherapy has numerous and severe side effects. To conduct localized (electro)chemotherapy, we designed a novel device that does not currently exist on the market. Electrochemotherapy is based on the cell membranes temp...

By Aleksandar Cvetković, Danijela Cvetković, Danko Milašinović, Nemanja Jovičić, Nikola Miailović, Dalibor Nikolić, Slobodanka Mitrović, Nenad Filipović

Heart wall tissue plays a crucial role in living organisms by generating the mechanical force for blood flow. This tissue has a complex internal structure comprised mostly of muscle cells, in which biochemical energy is transformed into mechanical active stress under rhythmical electrical excitation. The overall heart functioning depends, among oth...

By Miloš Kojić, Miljan Milošević, Bogdan Milićević, Vlada Geroski, Vlada Simić, D. Trifunović, G. Stanković, Nenad Filipović

Nowadays, finite element analysis is a well-assessed technique which enables investigation of blood vessels behavior under different boundary conditions. Given the rapid progression of both medical imaging techniques and computational methods, the challenge of using the simulation of human arteries such as carotid arteries to address different medi...

By Smiljana Djorovic, Igor Saveljic, Nenad Filipovic